Silence Therapeutics PLC Overview
Industry: Biotechnology
Sector: Healthcare
Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's mRNAi GOLD GalNAc Oligonucleotide Discovery platform that is used to target specific disease-associated genes in the liver. Its siRNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company develops SLN360, which is in phase 2 clinical development to reduce high levels of lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering siRNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform, as well as the company also collab with Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc was incorporated in 1994 and is headquartered in London, the United Kingdom. Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's mRNAi GOLD GalNAc Oligonucleotide Discovery platform that is used to target Read MoreMavefund brings filings, fundamentals, valuation, price history and news for Silence Therapeutics PLC into one research view. The sections below show what strengthens or weakens the research case.
Score
Reported Results
What the company reported, with filing details kept small.
Quarterly result summary
Revenue was $0.4M (reported). Net loss was -$15M. R&D expense was $9.1M.
Revenue
$0.4M
reported
Net loss
-$15M
reported
R&D expense
$9.1M
reported
G&A expense
$7M
reported
What changed
- Revenue reported to $0.4M.
Guidance / outlook
No formal outlook was extracted from this filing excerpt. Open the SEC source to review full management commentary.
Earnings material
Open filing
Source: SEC EDGAR company-filed earnings materials. Dates are shown only for verification; review the source filing before relying on extracted report details.
Other recent earnings materials
SEC filing
10-Q
May 07, 2026
SEC filing
8-K
May 07, 2026
SEC filing
10-K
Mar 05, 2026
SEC filing
8-K
Mar 05, 2026
Earnings release
Earnings release
Mar 05, 2026
SEC filing
10-Q
Nov 06, 2025
SEC filing
8-K
Nov 06, 2025
Earnings release
Earnings release
Nov 06, 2025
SEC filing
10-Q
Aug 07, 2025
SEC filing
8-K
Aug 07, 2025
Earnings release
Earnings release
Aug 07, 2025
Prediction-grade evidence
Recent News
Company-relevant articles from sources that pass the Mave Signal relevance and reliability checks.
SLN Stock Skyrockets 107% in Six Months: Here's What You Need to Know
Headline from Yahoo Finance UK: SLN Stock Skyrockets 107% in Six Months: Here's What You Need to Know.
Silence Therapeutics (SLN) Moves 7.2% Higher: Will This Strength Last?
Headline from Yahoo Finance Singapore: Silence Therapeutics (SLN) Moves 7.2% Higher: Will This Strength Last?
Earnings Per Share
Score 0.00/5
Silence Therapeutics PLC earns a low score, as its Earnings Per Share (EPS) has not shown continuous growth over the last six years. Notable counterparts in the sector with high scores includes
Zoetis Inc
IQVIA Holdings Inc
Agilent Technologies Inc
In
Biotechnology industry
, Halozyme Therapeutics Inc
, Corcept Therapeutics Incorporated
, Exelixis Inc
are companies with high ratings.
Return on Equity
Score 1.96/5
Silence Therapeutics PLC exhibits a lower score in the Return on Equity (ROE) section, falling below the sector median value and indicating a comparatively weaker performance in this metric. The top companies in the same sector include
Zoetis Inc
IQVIA Holdings Inc
Agilent Technologies Inc
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Net Margin
Score 2.21/5
Silence Therapeutics PLC
olds a low score as its net margin consistently trails below the sector median value and doesn't exhibit continuous growth over the last six years; notable companies in the sector with commendable scores include
Zoetis Inc
IQVIA Holdings Inc
Agilent Technologies Inc
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Leverage
Score 3.00/5
Silence Therapeutics PLC
attains a commendable score in the category due to its lower leverage ratio over the past six years in comparison to the sector median value. Additionally, other notable companies in the same sector, such as
Zoetis Inc
IQVIA Holdings Inc
Agilent Technologies Inc
, also exhibit high scores.
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Financial Statements
Company-reported SEC EDGAR facts organized into the three core statements.
Verified SEC statements load when this section enters view.
Source: SEC EDGAR companyfacts. Values are standardized company filings for research support, not personalized financial advice.
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